Thickness Test For Tablets
The test utilised to quantify how thick the tablet is is known as the tablet thickness test. To guarantee that the thickness of each tablet is within the predefined range as referenced in BMR, a thickness test for tablets is initially conducted after line clearance. Afterwards, it is worth taking a look at all through the pressure activity at determined time spans. The thickness Test for tablets is one of the most commonly and ordinarily involved tests for tablets, which is performed during the tablet compression operation.
Tablets are made utilising various shape tooling; a significant test is the control of the thickness of each tablet using a particular shape of tooling. We measure the thickness of the tablets by taking some example tablets to guarantee that the tablet thickness is within a predefined range. Measuring tablet Thickness is a very simple process that can be done by using any of the following instruments;
- Vernier Calliper – The vernier calliper gives readings in millimetres and is accessible both in digital display and manual reading. To gauge the tablet thickness place it in the middle of between the jaws and slide the scale jaw to press the tablet against the fixed jaw. The reading on the presentation is noted, and it is the real thickness of the tablet.
- Micrometre
- Thickness Gauge
The thickness of tablets is mainly affected by the following factors,
Tablet Weight – Tablet weight is straightforwardly connected with the tablet thickness, and that implies that if weight is increased, thickness is additionally expanded, as well as the other way around. The heaviness of the tablet is subject to die filling volume and granule size.
Die Filling – Die filling volume implies the filling of dies with powder or granules to pack the tablets. Die filling volume is straightforwardly connected with tablet weight, so if die filling volume isn’t uniform, the thickness of tablets won’t be uniform.
Granule Size – The size of granules is one more significant variable that is, by implication, connected with the tablet thickness. On the off chance that granule size isn’t uniform, die filling will be affected and the heaviness of the tablet won’t be uniform, so we might notice the variety in tablet thickness.
Tablet Hardness – Tablet hardness is straightforwardly relative to the applied pressure, utilising compression wheels, meaning that if we apply more pressure, hardness is increased, as well as the other way around. If we keep any remaining elements steady, i.e tablet weight and die filling volume, tablet thickness again may change, relying on the tablet hardness or applied compression force. On the off chance that tablet hardness is increased, tablet thickness is diminished and assuming tablet hardness is diminished, tablet thickness is expanded.
Tooling – Variety in tablet thickness may likewise be noticed in the event that our compression machine tooling isn’t in great shape. There might be variations in punch length because of over-the-top utilisation of tooling, which might diminish because of friction. Assuming the length of any lower punch is diminished, it might bring about higher tablet weight because of expanded die filling and resulting in expanded tablet thickness.
